Sentence examples for mutants with unknown from inspiring English sources

As negative control, the predictions differed greatly for the 251,414 mutants with unknown disease relation.

SNAP and SIFT predicted much more effect for disease related mutations than in mutants with unknown disease relation.

3G152V mutants and 2 Pler mutants with unknown mutation sites were cultured in F10A liquid medium for 6 days and then the titer of daptomycin was measured.

This finding cannot be inverted due to the overlap of score distributions of disease related mutants and mutants with unknown disease annotation (Fig. 1A, Additional file 1); i.e. strong effect on function does not imply disease.

However, much fewer mutants with unknown disease relation were predicted to significantly change function than the disease related mutations (Fig. 1B: strong effect for 14% of mutants unknown disease relation - dashed green line - vs. 48% of disease related mutations - dashed black line).

BRAF mutants with impaired or unknown kinase activity as well as concomitant kinase-impaired BRAF mutations and RAS mutations were detected in lung cancers, colorectal cancers and melanomas.

On the other hand, intercalated treatment might be a promising approach for patients with NSCLC with EGFR mutant disease or selected patient with unknown EGFR mutation status, according to several clinical studies [ 21– 23].

Genomic profiles were available for 8 KRAS mutant tumours, 31 wt and 16 tumours with unknown KRAS mutation status (untested SCC samples).

Twenty-four DNA samples from different sources were probed, some having known wild type or mutant TP53 sequences and others with unknown TP53 genotype.

The expression of MtNAP2, encoding a nodule specific protein with unknown function was reduced in all ineffective mutants compared to wild-type plants.

Furthermore, the expression of genes with unknown functions is also regulated by Fe deficiency, and a knockout mutant for a mitochondrial Fe-regulated gene shows sensitivity to Fe deficiency compared to wild-type (WT) plants (Ishimaru et al. 2009).