Sentence examples for mutations with unknown from inspiring English sources
Compared to the surgical precision of modern gene editing, these efforts were like using a sledgehammer, creating potentially hundreds of unpredictable mutations with unknown effects.
With the advent of multigene panel testing for breast cancer patients, germline mutations with unknown association with cancer risk, known as variants of uncertain significance (VUS), are being increasingly identified.
Human purpose, with the necessary limits of our knowledge, is now projecting mutations with unknown effects into an overall bio-system of which we have incomplete knowledge of all the feedback loops.
BRAF mutations with unknown kinase activity were not seen in CRC specimens.
(4) Set of mutations with unknown disease relation : We extracted 251,414 variants (28,913 proteins) without known disease associations.
GRN sequencing analyses in our cohort of FTLD patients also identified four different GRN missense mutations with unknown pathogenic nature in six FTLD patients.
PL11 with G152V mutation, LDR with unknown mutation site, and wild-type strains were cultured in fermentation medium and were measured the daptomycin titer and cell mass during the entire time course.
Nonetheless, with two out of the 24 tested UL cases of AA descent carried heterozygous FH mutations, albeit with unknown pathogenicity, screening for FH mutations in the entire NIEHS-UFS sample is worth an undertaking to unequivocally assess the spectrum of FH mutations in nonsyndromic UL and to evaluate the potential contribution of HLRCC to the UL pool in NIEHS-UFS.
Half of all human cancers lose p53 function by missense mutations, with an unknown fraction of these containing p53 in a self-aggregated amyloid-like state.
Another useful application would be the functional characterisation of myogenic cells that carry already genetically identified mutations with an unknown function.
Another mutational signature with unknown aetiology and mutations predominately at C > G at Tp C was also identified.
