Sentence examples for multiple mitotic defects from inspiring English sources

RNAi-induced depletion of hCdc14B causes errors in chromosome segregation, metaphase delay, multipolar spindles, and cell death due to accumulation of multiple mitotic defects.

Tim depletion caused multiple mitotic defects, including the loss of sister-chromatid cohesion, loss of mitotic spindle architecture, and a failure to exit mitosis.

For example, polo-like kinase 1 (Plk1) is a well-studied mitotic kinase whose inactivation leads to multiple mitotic defects and cell death.

Lack of OMCG1 in embryonic stem cells led to a similar cellular phenotype, with multiple mitotic defects and rapid cell death.

Upregulated survivin by TGF- β1 should act as a mitotic regulator and also activate Aurora B for cell cycle progression, so TGF- β1 leads to multiple mitotic defects and cell apoptosis when survivin is absent.

However, studying late mitotic functions of Plk1 is complicated by the fact that inhibition of Plk1 causes multiple early mitotic defects, most notably spindle defects [38].

Many of these cells contain multiple centrosomes, micronuclei and mitotic defects [ 10].

As a consequence, centromere function was impaired and mitotic defects, including multiple spindle attachments and aneuploidy, were observed [ 121].

Therefore, PLK-1 is one of the key players in mitosis, ensuring the proper regulation of G2/M onset; nevertheless, the deregulation of PLK-1 leads to multiple defects in metaphase, termed mitotic defects, and favors the promotion of aberrant cell survival.

The most common defect observed was multiple mitotic spindle poles rather than the expected bipolar structure.

MEFs Esco2 Δ / Δ show premature disjunction of sister chromatids and severe mitotic defects in the form of multiple chromosome bridges and lagging chromosomes observed in nearly all cells.