It seems plausible that the combined action of multiple mitotic, Cdk1-regulated, factors fine-tune mitotic exit.
HnRNPE1 is a member of the RNA binding protein family which includes important mitotic regulators and effectors, having multiple functions in hematopoietic cells.
Upregulated survivin by TGF- β1 should act as a mitotic regulator and also activate Aurora B for cell cycle progression, so TGF- β1 leads to multiple mitotic defects and cell apoptosis when survivin is absent.
The mitotic regulators Wee1 and Cdk1 can inactivate each other through inhibitory phosphorylations.
The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
The most common defect observed was multiple mitotic spindle poles rather than the expected bipolar structure.
Here, we engineered a bispecific antibody to detect K11/K48-linked K11/K48-linkedntified mitotichainslandrs, midentifiedascent polypeptides, and pathological Huntingtin variants as their endogenous substrates.
In Drosophila, mutation of the oncogene Myb reduced the expression of mitotic genes, such as polo and ial, and caused multiple mitotic defects, including disrupted chromosome condensation and abnormal spindles.
A set of mitotic regulators, including ubiquitination, proteasome degradation of mitotic factors, and PLK1, increase the dependency of KRAS-mutant cells on mitotic checkpoints and progression.
MELK-regulated phosphorylation of FOXM1 facilitates FOXM1 transcriptional activity and induces the expression of various mitotic regulators (e.g. Survivin, Aurora B, and CDC25B).
