By contrast, scoring proliferation by counting mitotic figures across multiple high powered fields showed a significant relationship with survival, suggesting that rate of cellular proliferation has an important influence on the behaviour of these tumours.
1 7 10 The strong correlation between pHH3 (Ser10) and mitotic index has been confirmed in multiple studies, 1 3 and the detection of mitotic figures via pHH3 (Ser10) IHC analysis has been described as having superior sensitivity due to enhanced detection of prophase cells and better specificity due to lack of staining in apoptotic cells.
In any event, inspection of the consensus sequences of the phosphorylation sites (Supplementary Figure 2B) suggests that multiple mitotic kinases contribute to control Ska3 function.
In Figure 6a, we can see multiple mitotic processes, including prophase, metaphase, and telophase with survivin in TGF- β1-treated cells.
Histopathology of biopsy from margin of ulcers revealed multiple signet ring cells, cellular pleomorphism, mucin secretion, abnormal mitotic figures and gland formation at certain places (figure 2B).
In the 17 α-AED-treated cultures, very few mitotic figures were present, and a substantial number of T98G cells contained multiple, cytoplasmic vacuoles which, in some cases, appeared to displace the nucleus.
Since the AJCC-TNM (tumor, nodes, metastasis) melanoma classification system was based on detection of mitotic figures from a data set where mitotic figures were reported on "routine" H&E sections, exhaustive examination of multiple levels to search only for mitotic figures is not warranted.
Carcinomas were characterised by frequent mitotic figures, apoptotic debris and cytologic atypia, such as amphophilic cytoplasm, increased nuclear-cytoplasmic ratio, hyperchromasia, prominent and multiple nucleoli, chromatin clumping and pleomorphism.
Occasional mitotic figures were seen.
