Sentence examples for multiple genetic defects from inspiring English sources

The current work suggests deletion of aflatoxin-biosynthesis genes is an ongoing process with genotypes retaining both varying percentages of the aflatoxin cluster and multiple genetic defects sufficient to cause non-aflatoxigenicity. Shared deletion patterns (Table 2; Fig. 2) suggest different deletion events lead to non-aflatoxigenicity in founding genotypes for the various lineages.

Most clinically apparent tumours contain multiple genetic defects with incompletely defined phenotypic consequences.

Tumorigenesis requires multiple genetic defects to transform a normal cell to a tumor cell [ 38, 39].

Advanced melanomas often have multiple genetic defects affecting diverse biochemical pathways.

Cancer is a genetic disease that is developed due to accumulated multiple genetic defects along human life span.

In the normal environment, multiple genetic defects are often required to elicit altered behavior 10, demonstrating robustness against genetic perturbations.

They hypothesized that multiple acquired genetic defects in large patches of mucosa in the upper aerodigestive tract make morphologically normal epithelium prone to dysplastic or malignant transformation [ 3, 39].

They found no correlation between advanced age and the kinds of chromosomal changes that cause Down syndrome, but suggested that a small proportion of older fathers may be at increased risk for transmitting multiple genetic and chromosomal defects.

But some older fathers did have an increased risk of having children with achondroplasia, and according to the published results, "a small fraction of men are at increased risk for transmitting multiple genetic and chromosomal defects".

Multiple genetic screens for NB lineage defects have identified a huge number of potential regulators (Neumüller et al., 2011; Slack et al., 2006; Sousa-Nunes et al., 2009), but we still do not know the regulatory network that controls self-renewal in NBs or how this network might be modified by the segregating determinants.

Although the natural history of prostate cancer is currently unknown, multiple etiologies have been hypothesized, including genetic defects [4], [5], [6].