[17] Consistently, various studies of Birc5 with conditional knockout mice have shown phenotypes with exaggerated apoptosis, with or without catastrophic mitotic defects.
A lack of pantothenate would result in slow growth, delayed septation, and mitotic defects.
Polo-like kinase 1 (plays plays key roles in regulating various mitotic processes that are critical for cellular proliferation.
Two of the most potent survivin modulators, LLP3 and LLP9 at concentrations between 50 and 100 nM, caused delay in mitotic progression and major mitotic defects in proliferating human umbilical vein endothelial cells (HUVEC) and prostate cancer cells (PC3).
Tissue specific deletion of Survivin in thymocytes causes mitotic defects and cell death (Okada et al., 2004), clearly indicating that the pro-survival role of Survivin in vivo.
What's more, if these sites cannot be properly phosphorylated by Cdk1, mitotic defects can be induced in MCF10A cells (Zhang et al., 2015b).
Disorganization, not depolymerization, of mitotic spindles appears responsible for mitotic defects.
These phenotypes include nuclear morphology defects, DNA damage, mitotic defects, and aneuploidy.
Therefore, depletion of hCdc14B caused severe mitotic defects, including chromosome missegregation, erroneous mitotic spindle formation and binucleation.
Our data indicate that these mitotic defects are associated with low levels of activated RB1 and CAPD3, as well as other defects in the mitotic spindle checkpoint, suggesting a new role for RB1 in the mitotic defects of laminopathies.
