A lack of pantothenate would result in slow growth, delayed septation, and mitotic defects.
Nuclear overlapping, cellular pleomorphism and tumor necrosis of numerous mitotic figures (>4 per 10 high-power fields) are characteristics of aggressive clinical behavior [5, 6, 9].
Two of the most potent survivin modulators, LLP3 and LLP9 at concentrations between 50 and 100 nM, caused delay in mitotic progression and major mitotic defects in proliferating human umbilical vein endothelial cells (HUVEC) and prostate cancer cells (PC3).
Tissue specific deletion of Survivin in thymocytes causes mitotic defects and cell death (Okada et al., 2004), clearly indicating that the pro-survival role of Survivin in vivo.
What's more, if these sites cannot be properly phosphorylated by Cdk1, mitotic defects can be induced in MCF10A cells (Zhang et al., 2015b).
Disorganization, not depolymerization, of mitotic spindles appears responsible for mitotic defects.
These phenotypes include nuclear morphology defects, DNA damage, mitotic defects, and aneuploidy.
The tumor was composed of spindle cells with marked cytologic atypia and numerous mitotic figures, including abnormal mitotic figures.
Therefore, depletion of hCdc14B caused severe mitotic defects, including chromosome missegregation, erroneous mitotic spindle formation and binucleation.
