Sentence examples for multiple mitotic kinases from inspiring English sources

However, with the emerging role of multiple mitotic kinases in checkpoint recovery arise many intriguing questions, in particular, their regulation, mutual relationship, and implications to cancer.

In any event, inspection of the consensus sequences of the phosphorylation sites (Supplementary Figure 2B) suggests that multiple mitotic kinases contribute to control Ska3 function.

Increasing evidence suggests that p53 regulates the expression and function of many mitotic kinases and multiple mitotic kinases can also be involved in p53-mediated signaling by phosphorylation of p53, suggesting active interactions between p53 and mitotic kinases in the cell cycle regulation [ 50].

For example, polo-like kinase 1 (Plk1) is a well-studied mitotic kinase whose inactivation leads to multiple mitotic defects and cell death.

The APC/CCdh1 has multiple targets, including Cdc20, mitotic cyclins, mitotic kinases, and inhibitors of DNA replication origin licensing.

Phosphorylation events of multiple proteins by CDKs and other mitotic kinases are essential for the regulation of these processes.

Multiple nucleoporins, including members of the Nup107-160 complex, Nup98, and Nup53, are phosphorylated by mitotic kinases (Favreau et al. 1996; Glavy et al. 2007; Laurell et al. 2011; Macaulay et al. 1995; Mansfeld et al. 2006; Onischenko et al. 2005), and it is tempting to speculate that mitotic phosphorylation acts as a general mechanism to keep nucleoporins in a dissociated state.

Cells use multiple safeguards to prevent genomic instability by suppression or modification of DSB repair activities during mitosis, through the activation of mitotic kinases, CDK1 and PLK1.

Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis.

The morphological alterations occurring during mitotic entry are tightly coordinated with the cell cycle, mainly through the action of mitotic kinases.

The most common defect observed was multiple mitotic spindle poles rather than the expected bipolar structure.