Sentence examples for multiple immune defects from inspiring English sources

On this basis, the conception of the immune pathophysiology of sepsis dramatically evolved and now encompasses both an initial tremendous systemic inflammatory response responsible for organ failures and a compensatory anti-inflammatory response with multiple immune defects that may result in complex immunosuppression in some patients [31].

Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting.

However, advanced disease patients develop multiple immune defects, including hypogammaglobulinemia, deregulation of the cytokine network, or impairment of T and NK cells function [ 6].

On this basis, the conception of the immune pathophysiology of sepsis dramatically evolved and now encompasses both an initial tremendous systemic inflammatory response responsible for organ failures and a compensatory anti-inflammatory response with multiple immune defects that may result in complex immunosuppression in some patients [ 31].

We previously found that deficiency of mitochondrial tumor suppressor Fus1 results in multiple immune system defects, perturbed inflammatory response, aberrant cytokine expression, as well as dysregulation of mitochondrial homeostasis including generation of high levels of ROS.

This study demonstrates multiple T cell-mediated immune defects that are associated with HIV-1 gp120 in LN during the first 12 weeks of R5 clade C SHIV infection.

She is severely disabled – she has multiple immune disorders – and uses a wheelchair, owing to a spinal condition.

Preliminary data suggest that adoptive transfer of gene-corrected T cells can correct immune defects.

We have developed a lentiviral mediated gene therapy strategy to correct immune defects in XLP.

In contrast to other strategies that prime or boost cancer-specific immune responses, immune checkpoint blockade therapy targets tumor-induced immune defects and revives existing tumor-specific T cells to kill tumor cells.

Alternatively, obesity could be secondary to immune defects.