Sentence examples for mediate receptor internalization from inspiring English sources

Our findings with the Δ716-YTRF G-CSFR suggest that different processes and likely distinct subdomains in the G-CSFR mediate receptor internalization and degradation.

β-arrestin1 is an adaptor protein for GPCR, as well as non-GPCR, and it can mediate receptor internalization and signaling to the mitogen-activate protein kinases ERK, JNK, and p38 as well as Akt, PI3K, and RhoA [8].

On the other hand, for the apoptotic pathways, clathrin, AP-2 and Dyn first mediate receptor internalization.

These human anti-HER2-specific antibodies were capable of binding to surface expressed HER2 and inhibiting HER2 phosphorylation but did not mediate receptor internalization.

In contrast to the murine antibodies, human anti-HER2 antibodies induced by protein vaccination did not mediate receptor internalization and degradation.

Nonetheless, more potent vaccines targeting HER2 may be capable of generating higher-titer HER2-specific antibodies, and antibodies that not only bind but mediate receptor internalization and degradation, and the resultant loss of HER2 signaling.

The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially through intracellular protein interactions.

We next investigated the role of tyrosine residues in the cytoplasmic tail of the G-CSFR in mediating receptor internalization.

In addition to mediating receptor internalization, β-arrestins also serve as scaffold proteins, recruiting Src family tyrosine kinases to the phosphorylated GPCRs and consequently activate MAP kinases [21].

Our laboratory and others have previously shown that the mutation in the Δ716 G-CSFR deletes a critical domain that mediates receptor internalization and degradation [9], [26] [28].

Rspo1 has been shown to augment Wnt signaling by interacting with the low-density lipoprotein receptor related protein 5 or 6 (LRP5/6) coreceptor and inhibiting Dickkopf-1 (Dkk-1) mediated receptor internalization [ 9].