Sentence examples for mediate receptor desensitization from inspiring English sources

The PTH1R has pleiotropic signaling capacity, coupling to Gs, Gq/11, and Gi/o family heterotrimeric G proteins, and binding arrestins, which mediate receptor desensitization and arrestin-dependent signaling.

β-arrestins are multifunctional proteins that mediate receptor desensitization and serve as important signaling scaffolds involved in numerous physiopathological processes.

Originally identified as proteins that mediate receptor desensitization (4, 30) and internalization (17, 23, 24), work over the past two decades has demonstrated that arrestins also mediate G protein-independent signaling for multiple GPCR types [for review, see DeWire et al. (11)].

The C-terminal intracellular domain of CCR2 is critical for mediating receptor desensitization and internalization [4].

By binding to agonist-activated G protein-coupled receptors (GPCRs), beta-arrestins mediate homologous receptor desensitization and endocytosis via clathrin-coated pits.

Thus, we hypothesized that the hyporesponsiveness observed in sepsis could result from signal adrenergic receptor desensitization mediated by GRK2 via a NO-dependent mechanism.

Beta-arrestin and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

Seven-transmembrane receptors, like those for C5a, also signal through a G-protein-independent pathway that involves the activity of β-arrestins – multifunctional adapter proteins that mediate signalling and also control receptor desensitization and trafficking 13, 31, 32.

A previous modeling study examined the role of ligand-induced homologous receptor desensitization in mediating cell gradient sensing [25].

Because cell gradient sensing in the steady state and the dynamic cell migration process are fundamentally different, our study not only improves the previous modeling study to test the role of receptor desensitization in mediating cell gradient sensing in 2D, but more importantly explores the importance of this mechanism for effective migration in complex gradient fields.

To overcome this limitation, in the present study, we further develop the model to test the role of ligand-induced homologous receptor desensitization for mediating cell gradient sensing in two-dimensional (2-D) ligand fields, and we performed computer simulations for the dynamic cell migration process in different configurations of ligand gradient fields.