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This study for the first time demonstrated the molecular size (10 kDa) and pattern of modification (reducing end modification) for BG34-10 to mediate macrophage internalization.
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Studies using blocking antibodies on several CD11b+ and CD11b− cells suggested that CD11b may play an important role in mediating macrophage internalization of BG34-10.
Mannosylated SLNas exhibited physical properties suitable for alveolar macrophage passive targeting, adequate rifampicin payloads (10 15%), and feasible drug maintenance within SLNas along the respiratory tract before macrophage internalization.
Presently, the identity of the UA transporter mediating macrophage response to UA has not been identified.
Administration of D-4F significantly abrogated UFP-mediated macrophage infiltrates.
Microglia mediate Aβ internalization through a nonsaturable, fluid phase macropinocytic mechanism.
Here we studied the endocytic processes that mediate cell internalization of the CGTs.
These results suggest that unlike the homologous gp130 molecule other cytoplasmic motifs in the G-CSFR mediate ligand/receptor internalization.
58 In contrast to TLR, CLR can mediate antigen internalization.
Thus, PHB1 can mediate the internalization of the adipose-specific peptide [ 38].
These receptors also mediate the internalization of the virus receptor complex.
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