Sentence examples for mediate toxin internalization from inspiring English sources

Further, the results presented here implicate glycoproteins as functional receptors that can mediate toxin internalization.

We appreciate that the reviewers found compelling the evidence that CTB binds to glycoproteins, and these binding events can mediate toxin internalization.

These findings refute the accepted opinion of solely CROP- mediated toxin internalization.

We concluded that uptake of TcdA might be predominantly mediated by the C-terminal repeats ensuring potent toxin internalization.

The relationship between the internalization time τ i and Ψ described in (27) is shown in Figure 8. Ψ was determined from simulated toxin internalization time courses as the time to internalize 5 · 10−14 M ricin.

Although the basis for the difference in potency between Stx1 and Stx2 is unclear, the B-subunit plays an influential role in mediating toxicity [21] [25], suggesting that differences in B-subunit activities, such as receptor recognition or toxin internalization, are responsible for the variation in potency.

Toxin internalization is mediated by LC binding to ganglioside GT1b [23] and synaptotagmin I and II which are transiently expressed on plasma membrane during vesicle recycling [24], as well as contribution of the heavy chain as a conduit for toxin internalization [25], [26].

Toxin-induced disturbance of the intestinal barrier function, monitored by reduction of transepithelial electrical resistance (TER), was measured as marker for toxin internalization.

In contrast, CTA1 was consistently detected in the cytosol of untreated HeLa cells after 2 hours of toxin internalization (n = 3).

Celastrol did not inhibit cleavage of MAPKK1, indicating that it did not block toxin internalization or the proteolytic activity of LF.

We next sought to determine whether celastrol inhibited either toxin internalization or the enzymatic activity of LF by monitoring cleavage of MAPKK1, a cytosolic target of LF.