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Pathogenic bacteria lacking the capability to produce siderophores have protein receptors that could recognize the iron protein complexes to mediate iron internalization inside the bacterial cells (Mickelsen and Sparling 1981; Sebulsky et al. 2000).
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CccA-mediated vacuolar iron storage was recently shown to mediate iron resistance (Gsaller et al, 2012).
Iron internalization was documented by chemical assay, ferritin induction, and loss of calcein fluorescence.
However, siderophores are not the only route for mediating iron transport inside bacterial cells.
Aspergillus fumigatus employs two high affinity iron uptake mechanisms, siderophore mediated iron uptake and reductive iron assimilation (RIA).
avrA gene product is an effector protein of TTSS and mediate Salmonella internalization and persistence by suppressing the host inflammatory response.
Microglia mediate Aβ internalization through a nonsaturable, fluid phase macropinocytic mechanism.
Here we studied the endocytic processes that mediate cell internalization of the CGTs.
These results suggest that unlike the homologous gp130 molecule other cytoplasmic motifs in the G-CSFR mediate ligand/receptor internalization.
58 In contrast to TLR, CLR can mediate antigen internalization.
Thus, PHB1 can mediate the internalization of the adipose-specific peptide [ 38].
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