Sentence examples for mediating receptor internalization from inspiring English sources

We next investigated the role of tyrosine residues in the cytoplasmic tail of the G-CSFR in mediating receptor internalization.

In addition to mediating receptor internalization, β-arrestins also serve as scaffold proteins, recruiting Src family tyrosine kinases to the phosphorylated GPCRs and consequently activate MAP kinases [21].

While these studies highlight the importance of GRK phosphorylation of GPCRs in mediating receptor internalization and desensitization, it is notable that partial internalization of Rog-A was still detected in response to higher doses of spiradoline, indicating that the receptor can be internalized through different mechanisms.

We have not examined the potential role of other dileucine motifs in the G-CSFR in mediating receptor internalizations.

Ad-HER2-ki vaccine-induced potent T cell and antibody responses in mice and the vaccine-induced polyclonal HER2-specific antiserum mediated receptor internalization and degradation much more effectively than trastuzumab.

β-arrestin1 is an adaptor protein for GPCR, as well as non-GPCR, and it can mediate receptor internalization and signaling to the mitogen-activate protein kinases ERK, JNK, and p38 as well as Akt, PI3K, and RhoA [8].

Rspo1 has been shown to augment Wnt signaling by interacting with the low-density lipoprotein receptor related protein 5 or 6 (LRP5/6) coreceptor and inhibiting Dickkopf-1 (Dkk-1) mediated receptor internalization [ 9].

The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially through intracellular protein interactions.

Ren, X-R, Wei, J, Lei, G, Wang, J, Lu, J, Xia, W, Spector, N, Barak, LS, Clay, TM, Osada, T, Hamilton, E, Blackwell, K, Hobeika, AC, Morse, MA, Lyerly, HK, and Chen, W. "Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.

Our findings with the Δ716-YTRF G-CSFR suggest that different processes and likely distinct subdomains in the G-CSFR mediate receptor internalization and degradation.

Our laboratory and others have previously shown that the mutation in the Δ716 G-CSFR deletes a critical domain that mediates receptor internalization and degradation [9], [26] [28].