These complexes mediate receptor signaling, trafficking, and degradation.
PLL peptide do not mediate receptor mediated adhesion rather it modulates cell adhesion via non receptor mediated electrostatic binding mechanism [4].
Thus, BPA binding to AR interferes with nuclear receptor translocation.
Human homologues of receptors that mediate pigment translocation in melanophores are thought to be involved in processes such as appetite suppression and tanning, making them attractive targets for drugs.
Different from macroautophagy, CMA is a selective form of autophagy through which single cytoplasmic proteins containing a recognition motif (the pentapeptide KFERQ) are bound by a cytoplasmic chaperone complex and delivered to a lysosomal receptor, which mediates the translocation of the CMA substrates into the lysosomal lumen, allowing their degradation (Kaushik & Cuervo, 2012).
The receptors that are hypothesized to mediate begomovirus translocation into the salivary glands of B. tabaci, which is a requisite to transmission, and their genes, are presently unidentified.
Moreover, RfBP adopts a ligand-receptor binding manner [ 13, 31, 32] to mediate riboflavin translocation into the growing embryo [ 25].
Botulinum neurotoxin structure consists of light chain (LC) - the protease domain responsible for enzymatic cleavage of SNARE proteins, and heavy chain (HC) whose receptor domain which mediates binding to membrane receptor and translocation domain mediates toxin translocation into neurons.
In addition to HDACs 1 and 4, the down regulation of HDAC6 is of particular interest because HDAC6 mediates nuclear translocation of the androgen receptor via deacetylation of Hsp90 in castrate-resistant PrC cells [ 30].
It involves the participation of members of the karyopherin family of nuclear transport receptors, which are soluble carriers that mediate the regulated translocation of proteins across the nuclear envelope.
