Sentence examples for mutations at single from inspiring English sources

In the landscape model, single mutations at single sites among n sites affect the contribution of k other sites to fitness.

Since we found that two mutations at single amino acid positions strongly affect VHH binding (Table 2), these results are in agreement with the possibility that differences in amino acid residues located close to, or in, the active site might result in the lack or decreased inhibition of some TcTS members by the llama antibodies.

Thus, we hypothesised that relationships of more intermediate age are more appropriate for GS, and developed a haplotype-based relationship matrix, G H, since recombination of haplotypes occurs more frequently than mutations at single SNPs.

However, this approach may not detect mutations at single TALEN sites where the restriction site is not disrupted; hence, our results may under-represent the actual mutation rates present in individual animals.

This trio-sequencing approach not only enables accurate determination of the mutation rate but also importantly allows for precise identification of de novo mutations at single nucleotide resolution (Veltman and Brunner 2012).

Our study focuses on the deleterious mutations at single-based level.

Here we present the validation of a microfluidic-chip-based method for detecting EGFR multi-mutations at single-cell level.

To address this requirement, we developed a simple microfluidic chip to simultaneously finish on-chip cell identification and in situ cell lysis for detecting EGFR multi-mutations at single-cell level.

For cell samples fewer than 105 cells, the emerging microfabrication technologies have advanced the examinations of protein expression or gene mutation at single-cell level by preciously controlling single cells and their surrounding environments.

Adaptive evolution of multiple traits through multiple mutations at a single gene.

Taken together, these findings highlight the remarkable ability of RT to use separate mutations at a single position to acquire NRTI resistance through three different mechanisms.