Sentence examples for mutations at actionable from inspiring English sources

The WUCaMP assay uses targeted capture for NGS analysis of 25 cancer-associated genes to detect mutations at actionable loci.

Identification of clinically-actionable mutations at an early stage could lead to targeted treatment before tumor heterogeneity and multiple genomically-distinct clones that are resistant to therapy can evolve.

The simultaneous sequencing of the germline DNA along with the tumor DNA therefore offers technical advantages to identify somatic mutations at low allelic fraction and increases the opportunity to identify actionable inherited variants.

Importantly, a large number of these oncogenic mutations are potentially actionable with novel therapies.

A number of the "driver" gene mutations are considered "actionable" as they have diagnostic, prognostic, or predictive implications.

Few studies have looked for EGFR mutations and other "actionable mutations" in OSCC, and most to date have been conducted in small heterogeneous HNSCC patient cohorts.

To determine if samples with high artefacts contain mutations that mimic actionable mutations, we selectively examined the variant calls from samples with high artefact rates.

We also evaluated the ability of the Ion Torrent DNA mutation panel to find actionable mutations in our patients for incorporation into future studies.

"Such a baseless accusation is at best offensive and at worst actionable," Mr. Grandeau wrote.

While several of these mutations may be deemed actionable, no effective treatments have yet been developed that target a majority of these mutations, with the exception of DNA repair and androgen receptor (AR) mutations.

Altogether, these observations suggest our approach has a greater sensitivity to detect mutations in potentially clinically actionable genes.