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Also, second-site mutations at other genes can act as suppressors, restoring wild type function.
In contrast, many mutations at other positions in TM14 exhibited reduced substrate-binding affinities.
Non-synonymous mutations at other residues, and in particular 57 and 61, were not observed.
This is in line with the theoretical prediction that genes that are better able to buffer genetic mutations at other loci will evolve higher genetic robustness.
In our analysis it appears that selection at one locus does not have any affect on the distribution of mutations at other loci.
Mutations at other positions, possibly followed by subsequent mutations elsewhere in the protein either preserved (or restored) the original protein function or gave rise to a newly acquired one.
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Alanine mutation at other residues of the β7 β8 loop did not affect either RT stability or virus infectivity significantly.
The reason could attribute to smaller effect sizes of this mutation at other ages that had low power to uncover it.
Mutating Trp107f to Ala reduced pyruvate activity by five orders of magnitude, whereas mutations at all other positions had effects less than a single order of magnitude, including the canonical specificity residue at position 102.
To ensure processing at only the p2/NC site, we incorporated blocking mutations at all other major processing sites within pGPfs.
In human PRNP, the widely-studied A117V mutation, and a variety of synthetic alanine to valine mutations at 4 other positions in the hydrophobic tract increase biogenesis of a transmembrane form of the protein ("CtmPrP"), and may be a cause of Gerstmann Straussler Syndrome and neurodegenerative disease in transgenic mice, respectively [23].
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cancellations at other
developments at other
times at other
mutations at various
variations at other
mutations at alternative
mutant at other
mutations at early
mutations at residue
mutations at exposed
mutations at specific
mutations at multiple
mutations at high
mutations at hydrophobic
mutations at polymorphic
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