Sentence examples for variants at single from inspiring English sources

The novel techniques of molecular inversion probes (MIPs) combined with discontinuous rolling cycle amplification (DRCA) was developed for determination of the multi-nucleotide variants at single base.

This MIPs-DRCA method which could be applied to simultaneously genotype multi nucleotide variants at single base, such as K-ras gene, was very feasible for determination of genetic diseases in clinical.

Contributions of nicotinic receptor gene variants to individual differences in smoking quantity [6] [10] and acetaldehyde dehydrogenase/alcohol dehydrogenase variants to risk for alcohol dependence in Asians may provide larger effects of variants at single loci [11], [12].

The influence of genetic variation on epigenetic marks has been previously demonstrated by the association of specific genetic variants at single nucleotide polymorphisms with specific DNA methylation sites [ 53]; it is therefore possible that somatic mutations or copy number variations in MZ twins may lead to epimutations in a cell- and tissue-specific manner.

Here, we introduce methods that estimate the total trait variance explained by the typed variants at a single locus in the genome (local SNP heritability) from genome-wide association study (GWAS) summary data while accounting for linkage disequilibrium among variants.

Although, the conditions that trigger production of so many structural variants at a single point of time in any given cyanobacteria have not been clearly understood, few studies have shown that production of protease inhibitors from laboratory cultures is affected by light, temperature, nitrogen and phosphorus concentrations.

We highlight the effectiveness of the optical mapping system in providing detailed characterization of structural variants at the single molecule level using two exemplar large scale studies ([ 3, 10]).

However, previous studies examining transcribed sequences in cultivated potato indicated that tri- and tetra-allelic variants at a single nucleotide level are rare (C. R. Buell and J. P. Hamilton, unpublished results).

Although several techniques for the simultaneous detection and quantification of multiple variants at a single locus have been described previously [ 25- 27], the QSS method has several advantages making it an interesting alternative.

Another immediate need is high-throughput functional assays to experimentally validate that individual sites do impact gene expression [ 40], and eventually to establish whether and how multiple variants at a single locus function together.

Taken together, our analyses of the F1 mapping population and the two doubled haploid lines show that we can distinguish segregating allelic variants at a single locus from fixed differences between paralogs, even in the face of extensive gene duplication.