Sentence examples for mutations at high from inspiring English sources

However, they will cause damages including protein carbolynation, lipid peroxidation, and DNA mutations at high levels, which contribute to disruptions of cellular homeostasis (Dan Dunn et al., 2015).

The mouse tumors contained activating NOTCH mutations at high frequency.

Our results are similar to a previous study by Kelliher and coworkers [25] using TAL1 transgenic mice, which acquire NOTCH1 mutations at high frequency.

Yet, the mechanistic basis for the beneficial effect of rpoB mutations at high temperature remains unclear.

All populations exhibit specific HEXA founder mutations at high allelic frequencies.

In previous work, we found that somatic mutagenesis frequencies in excess of 7% were sufficient to recover germinal mutations at high frequency (Zhang et al. 2010).

It would be difficult to evaluate the effect of single mutations at higher rates of μ.

Increases in DDT and pyrethroid resistance, as observed in most areas, were generally associated with an increase in the relative frequency of the S molecular form carrying the kdr mutations at higher frequencies.

One possible explanation is the presence of two subclones: assuming the seven mutations at higher allelic fraction are present in a heterozygous sate in a major founder clone (28% of the cells, 14% of the DNA) from which a minor clone arose, adding five heterozygous mutations (26% of the cells, 13% of the DNA).

Selection for leanness in domesticated pigs created an overdominant situation maintaining the mutation at high frequency until a DNA based diagnostic became available that enabled the targeted culling of individuals bearing the Halothane mutation [16].

In conclusion, we report one of the largest studies in women with a proven mutation at high risk of hereditary ovarian cancer in a single institutional setting.