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Earlier work had found that mutations at multiple sites on the fish's genes were implicated in the evolutionary loss of vision.
However, introducing mutations at multiple sites requires multiple steps of DNA manipulation, which is time-consuming and labor-intensive.
We study the evolution of the rate of self-fertilization in response to deleterious mutations at multiple loci.
It may be that once purging is overwhelmed by mutations at multiple loci, the linkage disequilibrium generated by selfing traps populations at a level of reduced fitness.
However, such tight linkage can potentially limit the effectiveness of purging via selfing if deleterious mutations at multiple loci are too numerous to segregate out among a fixed number of offspring [22].
The efficacy of purging is therefore limited by the total number of genotypes that can segregate within an individual cross, and thus mutations at multiple loci within a lineage have the potential to overwhelm purging and to drive the fixation of deleterious mutations [22].
Similar(34)
The frequencies of 9 mutations incrementally increased over the past 5 years, with mutations identified at multiple sites.
However, widespread linkage disequilibrium generated and maintained by self-fertilization is predicted to reduce the efficacy of purging when mutations are present at multiple loci.
The resistance phenotype observed in this stepwise process appears as a consequence of progressive increments during the whole procedure, suggesting that mutations are acquired at multiple steps.
MLVA provided discrimination among the otherwise indistinguishable isolates from different animals and from within each host, with VNTR mutations being detected at multiple dates and tissue sites.
Overall, I wonder whether the V41P mutation reduces integration at multiple points in the absence of CT8, and as such, whether analysis of this sample adds definitive information to Figure 3D.
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