Sentence examples for multiple downstream mechanisms from inspiring English sources

Additionally, it stimulates multiple downstream mechanisms (Fukao & Bailey-Serres 2008).

Timp1 inhibits myofibroblast apoptosis [ 64], for example, whilst Mmp13 could contribute to fibrosis resolution via activation of latent hepatocyte growth factor and multiple downstream mechanisms [ 65– 65].

When taken together, these findings highlight the multiple downstream mechanisms that contribute to the clinical phenotype of ostensibly simple single-gene (monogenic) disorders.

AKT signaling has been reported to promote cell survival and proliferation across different cell types and can involve multiple downstream mechanisms including activation of FRAP1 (mTOR)/P70S6K1, inactivation of CDKN1B (p27Kinactivationatiof oForkheadad family transcription factors, and increased cyclin D1 (CCND1).

This also suggests the possibility of redundant downstream mechanisms in growth cone inhibition by UNC-5, i.e. full-length UNC-5::GFP might engage multiple downstream mechanisms more robustly than MYR::UNC-5, and loss of one pathway does suppress this effect.

It is plausible that multiple stress kinases employ similar downstream mechanisms to mediate their functions, and perhaps do so in a context-dependent manner.

Thus, GDF-15 might not only be a marker of ongoing tissue damage but actively influence multiple downstream signaling effectors as part of a cardioprotective mechanism.

Studies on the genetic mechanism of evolutionary redeployments of multiple downstream genes have largely focused on transcription factors, as individual transcription factors are capable of regulating large numbers of target genes (Hoekstra and Coyne, 2007; Moczek, 2008; Stern and Orgogozo, 2008; Craig, 2009).

In this case, focusing on the uptake mechanism would also be an effective strategy, even if multiple downstream pathways are involved.

Moreover, despite knowledge of disease pathogenesis, it is possible that such mechanism-targeted therapies may not always be effective, if multiple downstream pathways contribute to disease pathogenesis.

Indeed, the capability of miRNA-125b in simultaneously regulating multiple downstream pathogenic gene targets may play a key role in explaining the complex multigenetic mechanisms underlying glioblastoma multiforme, an aggressive grade IV astrocytoma with a 1-year median survival rate and dismal prognosis despite current treatment modalities [ 57, 58].