Sentence examples for multiple downstream substrates from inspiring English sources

AMPK can directly phosphorylate multiple downstream substrates to inhibit ATP-consuming biosynthetic pathways and promote catabolic ATP regenerating processes to restore intracellular energy levels.

Activated Lck, Fyn, and ZAP-70 then phosphorylate multiple downstream substrates, including linker for activation of T cells (LAT) and the tyrosine kinase Pyk2 [7], [8], [8].

Nevertheless, the mechanism of action of FAK is complex and probably involves multiple downstream signalling substrates.

Furthermore, the caveolin-1-mediated increases in AKT activity were sufficient to cause the sequential phosphorylation of multiple downstream AKT substrates that included GSK3, FKHR and MDM2 Lii et al, 2003).

Two homologues exist, MEK1 and MEK2, which have only one known substrate, ERK1/2, which has multiple downstream effectors involved in a number of cellular functions including transcription (e.g. Elk1), cell cycle progression (e.g. Rb) and cell motility (e.g. JNK) (Sebolt-Leopold and Herrera, 2004).

Activated EGFR then phosphorylates its substrates, resulting in activation of multiple downstream pro-survival pathways involved in cell proliferation.

Notably, all single KR mutation tested exhibited attenuated Oct4 acetylation status (Fig. 4D), indicating that p300-mediated Oct4 acetylation occurs on multiple sites 16, 58, which has been reported in many of p300 downstream substrates.

In addition, second messengers can have multiple downstream targets, thereby expanding the scope of signal transmission.

Additionally, it stimulates multiple downstream mechanisms (Fukao & Bailey-Serres 2008).

Mutant KRAS can then promote tumorigenesis through multiple downstream signaling pathways.

Note in particular the output "sparse training set" that is used in multiple downstream locations.