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Clinically resistant strains often contain multiple resistance mechanisms, which may contribute to resistance in either an additive or multiplicative fashion [4] [6].
The observation that chemo-resistant tumors are significantly more diverse molecularly than chemosensitive tumors implies that multiple resistance mechanisms may be active, thus limiting the sensitivity and accuracy of predictive markers of chemotherapy response.
We observe multiple resistance mechanisms in 46% of patients after treatment with first-line inhibitors, indicating frequent intra-patient heterogeneity.
Zhai, D., Deng, W., Huang, J., Rogers, E. & Cui, J. J. TPX-0005, ALK/ROS1/TRKTRK inhibitor, overcomes multiple resistance mechanisms by targeting SRC/FAK signaling [abstract].
Several recent studies from our laboratory and others have investigated the causes of acquired resistance to BRAF and MEK inhibitors, and multiple resistance mechanisms have been identified.
The sequential use of different cancer therapies when an initial treatment is not successful is routine practice, but could lead to the development of multiple resistance mechanisms, and ultimately to resistance to any of the therapies.
Similar(13)
Awolola, T. S. et al. Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria.
These organisms possess multiple drug resistance mechanisms, with drug efflux being a significant contributing factor.
There is considerable evidence to suggest that the interaction of multiple insecticide resistance mechanisms or genes is responsible for the development of insecticide resistance [ 5, 7- 17].
These data indicate that a high number of isolates probably have resistance due to impermeability or multi-drug efflux or a combination of multiple unrelated resistance mechanisms.
SA is known to induce multiple virus resistance mechanisms [ 41],[ 42] and RDR1 is only one of the components involved in this mechanism.
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