Sentence examples for multiple downstream genes from inspiring English sources

Furthermore, master regulators including transcription factors are also promising target to be engineered because stress tolerance is determined by many cooperative factors and modification of master regulators can simultaneously affect the expression of multiple downstream genes.

On the other hand, our data show that the well characterized binary natural behavior polymorphism Rover/sitter affects multiple downstream genes and cellular systems.

SIM motif denotes a topology where a master gene regulates multiple downstream genes.

As a selector gene, ap is known to regulate multiple downstream genes (Bronstein et al. 2010).

Next, we hypothesized that expression differences of anchor genes would cause expression differences (in trans) on multiple downstream genes (targets).

It is known that SP1 activation augments the angiogenic and metastatic capacity of tumour cells through overexpression of multiple downstream genes, including VEGF (Shi et al, 2001).

Increased HIF-1α protein in cancer cells translocates to the nucleus, complexes with HIF-1β and activates multiple downstream-genes involved in angiogenesis (VEGF), metabolic adaptation (Glut1), vascular stability and metastasis (MMP2) and, ultimately survival; thereby driving tumor progression [ 2, 24].

Increased expression of HIF-1α then drives the expression of multiple downstream target genes (VEGF, glucose metabolic enzyme genes, Snail, Twist, Zeb, and so on) to promote processes such as EMT, angiogenesis, and acquisition of stem cell-like traits.

Wild-type secretory ameloblasts constitutively utilize the UPR as they exhibit increased levels of activated IRE1 and its downstream target XBP-1 (16), a transcription factor targeting multiple downstream target genes the majority of which are involved in increasing the folding capacity of the ER or with the degradation of proteins accumulating in the ER (22, 23).

Under hypoxic stress, HIF-1 activity is induced to control expression of multiple downstream target genes, including vascular endothelial growth factor (VEGF).

These TFs regulate expression of multiple downstream target genes under stress conditions.