Sentence examples for multiple downstream pathways from inspiring English sources
Endurance of activated signaling pathways by EPO/EPOR is regulated by various mechanisms such as availability of adaptor proteins, endocytosis of EPO/EPOR43, expression of specific phosphatases, and cross-talk between multiple downstream pathways of EPO/EPOR44.
Yoon, J. W. et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation.
Increased intracellular calcium modulates amyloid precursor protein processing and affects multiple downstream pathways including increased hyperphosphorylated tau and suppression of autophagy.
Biased agonists, which signal with different efficacies to a receptor's multiple downstream pathways, are useful tools for deconvoluting this signaling complexity.
As shown in Additional file 1: Figure S1, all these selected genes were induced in the PAH-degrading process, indicating that consortium CY-1 wableble to completely mineralize phenanthrene at a wide range of salinities via multiple downstream pathways, namely, the C23O, C12O, G12O and P34O pathways.
In this case, focusing on the uptake mechanism would also be an effective strategy, even if multiple downstream pathways are involved.
The existence of multiple downstream effector pathways that converge on common biological outcomes suggests that these pathways might function redundantly to some extent and thus provide robustness.
RAS maintains these cellular phenotypes by regulating the activation of multiple downstream effector pathways, including the RAF/mitogen-activated protein kinase (MEK /extracellular signal-regulated kinase (ERK) signaling pathway.
The resulting mutant protein, JAK2V617F, is a constitutively activated kinase that activates multiple downstream signaling pathways, such as the signal transducer and activator of transcription, extracellular signal-regulated kinases and Akt signaling pathways, and it transforms hematopoietic cells to cytokine-independent growth.
Mutant KRAS can then promote tumorigenesis through multiple downstream signaling pathways.
Since Hsp90 inhibitors are able to inhibit multiple downstream signaling pathways of mutant KRAS, there has been significant interest in testing Hsp90i in KRAS mutant NSCLC.
