Sentence examples for multiple downstream targets from inspiring English sources

In addition, second messengers can have multiple downstream targets, thereby expanding the scope of signal transmission.

Ca2+ influx via TRP channels is essential for rapid kinetics, amplification, and light adaptation, and mediates both positive and negative feedback via multiple downstream targets, including calmodulin (CaM), both TRP and TRPL (light-activated nonspecific cation channel encoded by trpl gene) channels, PKC, and PLC.

Compared to miR-21 and miR-10a that directly target IL-12 genes, some other miRNAs target the signaling components that will affect multiple downstream targets.

It can be activated by phosphorylation and subsequently activates multiple downstream targets to enhance cell survival.

DAC inhibitory activity of AR-42 was assessed by examining acetylation of multiple downstream targets in CLL patient cells.

Our data suggests that in Tregs from T1D subjects, both the AKT and p53 pathways exert pro-apoptotic function through transcriptional regulation of multiple downstream targets that render the cells sensitive to apoptosis.

These TFs regulate expression of multiple downstream target genes under stress conditions.

In addition, nuclear hormone receptors can regulate multiple downstream target genes.

A complex axonal branching pattern of interneurons allows single neurons to signal multiple downstream target neurons.

Thus, rapamycin acts at a level in the TOR pathway that captures multiple downstream target processes to extend life span.

The most important self-renewal signaling pathways include WNT/b-catenin, NOTCH, and Hedgehog, each of which has multiple downstream target proteins and genes.