Sentence examples for multiple downstream modules from inspiring English sources

Although the consequences of their interactions with the IRE1 signaling pathway on cell survival are unknown, they raise the possibility that IRE1 employs multiple downstream modules besides XBP1 generation to regulate cell fate after activation by protein misfolding.

For example, examining unidirectional edges related to DNA damage agents, such as hydroxyurea and camptothecin, we find multiple upstream and downstream modules (Fig. 8A).

Interestingly, through our tests to determine the effectiveness of targeting multiple inhibition sites as a means of combination therapy, we discovered a higher level of system sensitivity to targets in the downstream modules (Raf, MEK and ERK) as opposed to targets in the upstream modules (EGF and Grb2).

Additionally, it stimulates multiple downstream mechanisms (Fukao & Bailey-Serres 2008).

Mutant KRAS can then promote tumorigenesis through multiple downstream signaling pathways.

Note in particular the output "sparse training set" that is used in multiple downstream locations.

These TFs regulate expression of multiple downstream target genes under stress conditions.

Overall, we show that iterative modules are remarkably adaptable while downstream modules are gatekeepers that select for correct polyketide chain length.

An example of such a module is generated from interferon regulatory factor 1 (IRF-1), which is identified as one of the "divergence" hubs functionally linked to multiple downstream targets.

PHR proteins function through multiple downstream signaling pathways.

LIF/Stat3 signaling activates multiple downstream targets in mESCs.