Sentence examples for multiple downstream effects from inspiring English sources

Inhibitors of PI3K, Akt and mTOR have been shown to sensitize selected tumor cells to cytotoxic drugs through multiple downstream effects.

The example of GM-CSF mediated induction of IL-1β, a known mediator of atherosclerosis, provides an illustration of how CX3CL1 and GM-CSF may have multiple downstream effects to augment atherosclerosis.

There could be multiple downstream effects of PP-1 inhibition and/or PKA activation, including the sustained phosphorylation and constitutive activation of Akt that is observed in Herceptin resistant cells.

Hence, inhibition of catalytic activity by Nur77 can repress PKC-mediated activation of AP-1 and NF-κB, with multiple downstream effects including preventing induction of anti-apoptotic genes.

Metformin-mediated AMPK activation triggers multiple downstream effects that cooperate to restrain tumor growth.

Activation of platelets via PAR1 cleaved by thrombin leads to multiple downstream effects and observable phenotypic changes, including granule release and shape change characterized by extended pseudopodia.

Catecholamines (isoproterenol, norepinephrine, dobutamine, dopamine) increase cAMP through receptor-mediated increases in cAMP production with multiple downstream signaling effects.

The accumulation of AGEs and activation of AGE receptors results in multiple downstream pathogenetic effects leading to microvascular damage.

However, the large numbers of differentially expressed genes would seem to indicate that the effects of the lesions accompanying domestication have had multiple cascading downstream effects on the machinery of trichome initiation and subsequent primary and secondary wall synthesis.

Some SNPs may lead to multiple and diverse downstream effects, e.g. altered transcriptional response and manifestation of disease (Sakuntabhai et al., 2005).

A tantalizing hypothesis for further study is that multicellular organisms have evolved multiple FGUs of similar or complementary function as a means to mitigate this vulnerability, which was proven to be the case in both our examples where each of the putative upstream FGUs are regulating multiple downstream FGUs of similar effects.