Sentence examples for multiple downstream cascades from inspiring English sources

Activation of AKT in human cancers induces multiple downstream cascades to promote cell survival, tumor growth and progression.

The connection between RANK and RANKL induces recruitment and activation of TRAF6, which leads to multiple downstream cascades.

The oncogenic effects of AKT in human cancers depended on its ability of inducing multiple downstream cascades to promote cell survival, tumour growth and progression (Bellacosa et al, 1998; Franke et al, 2003; Osaki et al, 2004).

Together, our results confirm that IGF-1R signaling incites multiple downstream cascades in which the key MAPK/ERK and PI3K/Akt components constitute the central signaling nodes that regulate IGF-1/IGF-1R signal-mediated proliferandon antiestrogenogen resistance in MCF7/IGF-1R cells.

Aberrant expression of these receptor kinases in tumor cells alters multiple downstream signaling cascades that ultimately drive the malignant phenotype by enhancing tumor cell proliferation, invasion, metastasis, and angiogenesis.

Integrin clustering and recruitment of FAK to focal adhesions result in activation of multiple downstream signaling cascades including pro-survival PI3K/Akt pathway, which can activate Nrf2 signaling [50], [51]; thus, increased cell adherence would be predicted to result in upregulation, not downregulation, of Nrf2 pathway.

Gα·GTP and Gβγ subunits regulate the activity of target effector proteins such as adenylyl cyclases, phospholipase C isoforms, ion channels, and phosphodiesterases, which in turn regulate multiple downstream signaling cascades that initiate key biological processes such as development, vision, olfaction, cardiac contractility, and neurotransmission [1] [3].

Signals transduced through these components activate multiple downstream signaling cascades, inducing changes in cellular metabolism, gene expression, and cytoskeletal organization.

FSH activates multiple downstream signaling cascades in granulosa cells, including PKA, PI3K, PKB/AKT, p38-MAPK and ERK1/2.

Growth factors such as insulin-like growth factor (IGF) and epidermal growth factor (EGF) bind their cognate tyrosine kinase receptors and trigger multiple downstream signaling cascades such as PI3K/Akt and Ras-Erk/MAPK.

Its biological processes involve inflammation, angiogenesis, and cell survival and are mediated through the fibroblast growth factor-inducible molecule 14 (FN14) receptor, a finely tuned, inducible receptor encompassing multiple downstream signalling cascades.