Sentence examples for mediate upregulation of from inspiring English sources

What mechanisms mediate upregulation of Nrf2-dependent molecular chaperons in the setting of a global downregulation of Nrf2 pathway?

In addition, JNK signaling may in part mediate upregulation of FLI1 by C7ORF41.

In addition, connective tissue growth factor can also mediate upregulation of integrin subunits αv and β1 expressions in TM cells [ 57].

It is suggested that insulin resistance and inflammatory cytokines might mediate upregulation of the OPG release observed in humans and may reflect the endothelial dysfunction in subjects with diabetes [ 32].

The present study shows that high glucose can mediate upregulation of SR-A, CD36 and LOX-1, which could be related to initiation and progression of atherosclerosis in diabetes patients.

AEG-1 has been shown to mediate upregulation of MDR1 via the PI3K/AKT signaling and augmentation of translation [ 26], a mechanism key to AEG-1-mediated efflux of doxorubicin.

Compared with patients without OHSS, follicles from OHSS patients express higher levels of XBP1 s in cumulus cells, which partly mediates upregulation of VEGFA, a key molecule in angiogenesis in the ovary that is regarded as a major cause of OHSS induction (Kosaka et al., 2007; Takahashi et al., 2016).

We propose that FcγRIIb physiologically regulates allergic airway inflammation by two mechanisms: 1) allergen challenge mediates upregulation of FcγRIIb on pulmonary CD14+/MHC II+ mononuclear cells and CD11c+ cells by an IFN-γ dependent mechanism; and 2) by attenuating the allergen specific IgE response during sensitization.

Taken together, these findings indicate that DNA damage-mediate upregulation of p53 may be shifted to inhibitory p53 isoforms by CagA-positive H. pylori.

Smad4 thus mediates upregulation of VEGF by miR-146a.

10.7554/eLife.02313.009 Figure 3. Activated KRAS-mediated upregulation of ZNF304 is required for transcriptional silencing of INK4-ARF.