Sentence examples for mediate loss of from inspiring English sources

However, the molecular mechanisms that mediate loss of D2R in vivo remain unclear.

This is perhaps not surprising since these effectors have been characterised to mediate loss of stress fibres.

These SNPs are predicted to mediate loss of MREs, mostly through the gain of acceptor splice sites resulting in shortened 3′UTRs [64].

Nevertheless, in in vivo rat models of pulmonary hypertension where several mechanisms likely mediate loss of BMP signalling, we have shown that chloroquine can prevent onset and progression of disease (21).

Our results demonstrated that CASP2-mediated regulation of autophagy required ATG5 and ATG7; even low levels of ATG5 and ATG7 were sufficient to mediate loss of CASP2-induced autophagy, suggesting an involvement of the canonical pathway of autophagy.

To explore the wider gene network associated with Dom action, we used RNAi directed against domino (dom ) to mediate loss-of-function at the wing margin, a tissue that is readily scored for phenotypic changes.

Short hairpin RNA (shRNA) mediated loss-of-function screens in mammalian cells are powerful tools for the discovery of novel gene functions.

Since LATS1/2 and YAP/TAZ have opposing effects on drug response and LATS1/2 can inhibit YAP/TAZ function through phosphorylation [ 190– 192], we propose that YAP/TAZ-TEAD-Cyr61/CTGF is a novel signalling pathway mediating loss-of-LATS-induced drug resistance in the treatment of human cancers.

Once initiated, BAK mediates loss of the mitochondrial membrane potential that is required for oxidative phosphorylation, a reduction in cellular ATP level, and caspase independent cell death.

Due to the complexity of the structure of oral mucosal biofilms [9], transcriptional deregulation of a single C. albicans gene is unlikely to be responsible for mediating loss of the mucosal biofilm phenotype in the bcr1/bcr1 mutant.

PirB contributes to memory deficits present in adult mice and mediates loss of synaptic plasticity in juvenile visual cortex.