Sentence examples for mediate resistance of from inspiring English sources

For instance, BCL-2 mutations that abrogated binding of BH3 mimetics mediate resistance of ABT-199 in experimental lymphoma models [240].

Also KatG and AhpC mediate resistance of M. tuberculosis to isoniazid [16].

These results suggest that FopC may be required to mediate resistance of F. novicida to elimination by endogenous IFN-γ.

In addition, the involvement of p53 in VLA-4 pathway has been reported to mediate resistance of CLL cells to drugs.

In the present work, we have addressed this question by generating a mutant form of gal-7 (R74S) with altered subcellular localization and tested its ability to mediate resistance of breast cancer cells to drug-induced cell death.

We investigated whether miRNA21 mediates resistance of CCA cells and organoids to HSP90 inhibitors.

We therefore hypothesised that LYS-7 may play an important role in mediating resistance of the worm towards C. neoformans.

Our previous work showed the importance of activated AKT in mediating resistance of non-small cell lung cancer (NSCLC) to AZD6244.

At least the latter contributes to innate immune responses mediating resistance of G. mellonella larvae against normally lethal infection by the human pathogenic yeast C. albicans [ 14].

In 2008, researchers found that the loss of expression of IGF-binding proteins (IGFBPs) in tumor cells treated with EGFR-TKIs increased the activation of IGF-IR signaling which, in turn, mediates resistance of EGFR-TKIs 26, 27.

We then arbitrarily selected the MCF7RasG12V clone (clone C) and investigated the potential roles of the two major Ras downstream pathways, PI3K/Akt and MEK/MAPK, in Ras-mediated resistance of MCF7RasG12V cells to treatment with paclitaxel, doxorubicin, and 5-fluorouracil.