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Integrin αvβ3 was proposed to mediate attachment of Pam3CSK4 to cell surfaces through binding of vitronectin attached to the lipopeptide.
The fimbriae or pili are nonflagellar, filamentous projections on the bacterial surface that mediate attachment of the organism to respiratory, gastrointestinal, and urinary tract mucosal cells.
Furthermore, it is a component of hemidesmosomes, which mediate attachment of epithelial cells [38].
Integrins mediate attachment of stem cells to the matrix in the niche.
It is tempting to speculate that integrin αvβ3 is responsible for attachment of Pam3CSK4 to the surface of the macrophages, since integrin αvβ3 was previously proposed to mediate attachment of Pam3CSK4 to cell surfaces [10].
To date, the most prominent model holds that upon activation via TRAF6 homo-oligimerization, the RING finger ubiquitin E3 ligase domain complexes with a K63-specific E2 conjugating enzyme (Ubc13/Uev1a, or possibly UbcH7) to mediate attachment of non-degradative K63-linked ubiquitin chains to TRAF6 substrates, specifically TRAF6 itself [4], [16].
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The HIV-1 gp120 envelope (Env) glycoprotein mediates attachment of virus to human target cells that display requisite receptors, CD4 and co-receptor, generally CCR5.
GOAT is the transferase mediating attachment of octanoate to the appetite-stimulating hormone proghrelin [30], [37] [39].
Further, PIM was suggested to act as adhesins mediating attachment of M. tuberculosis bacilli to non-phagocytic cells [27].
The kinetochore is a multi-protein complex that assembles at the centromere and mediates attachment of chromosomes to spindle microtubules to ensure accurate chromosome segregation at mitosis.
The kinetochore (KT) is the protein complex responsible for mediating attachment of sister chromatids to the mitotic spindle and for directing chromosome movements during mitosis.
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