Sentence examples for mediate repression of from inspiring English sources

Mahon, P. C., Hirota, K. & Semenza, G. L. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.

MicroRNAs (miRNAs) are ∼21 24 nucleotide RNAs that mediate repression of messenger RNA (mRNA) translation through recognition of specific miRNA binding sites usually located in the 3′ non-translated region.

However, Wnt/β-catenin could also mediate repression of Mstn indirectly, through induction of its direct target follistatin [48] that is a known negative regulator of Mstn [49].

HoxA1 was proposed to mediate repression of endodermal differentiation [41], which is consistent with higher expression of endodermal markers in Hoxa1−/− mouse ES cells.

Together, this suggests that different site-specific factors are involved in the recruitment of distinct H2A E3 ligases to mediate repression of a specific set of genes.

To determine if the PrrH RNA was able to mediate repression of these genes in response to heme, the ability of iron and heme to affect their expression was examined by qRT-PCR.

One such modification, the trimethylation of lysine 27 on histone H3 (H3K27me3) is required for Polycomb Repressive Complex 2 (PRC2) mediated repression of a large number of genes essential for cell proliferation, cell differentiation and tumor development [ 22, 23].

Zhao, Y. et al. MicroRNA-mediated repression of nonsense mRNAs.

DNA tethering of CNOT2 mediates repression of MHC II transcription.

Tuckermann, J. P. et al. The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin.

In primary erythroid progenitors, PRMT5 mediates repression of developmentally regulated β-globin locus [13].