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The third effect of some harpins is to serve as type III translocators, which are distinct in nature but function similarly to mediate translocation of type III effectors from bacterial cells into the cytosol of plant cells presumably by recognizing PM sensors2,18.
Our data show that dimeric SecA may mediate translocation of the preprotein in an asymmetric manner.
In the case of Autotransporters the b-barrel is proposed to mediate translocation of the passenger domain to the cell surface through the pore.
In the present study the activation of γδ+ T cells require live CagA positive bacteria but it was not observed after stimulation with the purified CagA protein alone, suggesting the need for metabolically active bacteria able to mediate translocation of CagA into the lymphocytes.
CPPs are able to mediate translocation of a conjugated cargo (e.g., anticancer therapeutics) across plasma membrane, providing an effective and nontoxic mechanism for drug delivery [ 8].
PIK3C2G possessing the C2 domain could mediate translocation of proteins to lipid membranes, and also regulate protein-protein interactions in human and mammals [ 45].
Similar(50)
Diphtheria toxin consists of an A-fragment that inactivates elongation factor 2 and a B-fragment that both binds to the toxin receptor and mediates translocation of the A-fragment across cellular membranes to the cytosol.
Chemokines and their receptors play an important role in the immune system by mediating translocation of leukocytes towards sites of inflammation [1].
The Sec pathway mediates translocation of protein across the inner membrane of bacteria.
The cag PAI encodes a T4SS that mediates translocation of bacterial virulence factors into the host cell [ 5].
C2IN is the enzymatic inactive domain of C2I, which interacts with C2IIa and mediates translocation of C2I- or C2IN-derived fusion proteins through C2IIa pores across endosomal membranes.
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