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Likewise, IDO can mediate suppression of T-cell immunity to MHC-mismatched liver allografts [3].
In vivo LAP utilized an IL-10-dependent pathway to mediate suppression of the cellular immune response.
Leukemia Inhibitory Factor induced in co-cultures of MSCs and lymphocytes was shown to mediate suppression of T cell proliferation [12].
Furthermore, whether a unique subset or all monocytes mediate suppression of NK cell mediated cytotoxicity against MSCs needs to be explored.
Recent studies have shown that the ES cell pluripotent state is critically maintained by Polycomb group (PcG) complexes that mediate suppression of key differentiation genes [12] [14].
Using animal models of MS like experimental autoimmune encephalomylelitis (EAE), CB1R and CB2R have been shown to be specific markers of MS plaque cell subtypes [21]; furthermore, CB1R has been proven to mediate suppression of CNS autoimmune inflammation on neurons, whilst CB2R had the same anti-inflammatory role on autoreactive T cells [22].
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The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation.
A nicotinic-like receptor mediates suppression of distortion product otoacoustic emissions by contralateral sound.
Mathur, G. et al. Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito.
Bouarab, K., Melton, R., Peart, J., Baulcombe, D. & Osbourn, A. A saponin-detoxifying enzyme mediates suppression of plant defences.
Linehan C, Gupta S, Samali A, O'Connor L. Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells.
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