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We therefore explored which of these proteins mediate survival of HF1 cells under stress.
Furthermore, p63 appears to mediate survival of thymic epithelial stem cells in vivo by providing protection from programmed cell death [21].
The nature of the imatinib-sensitive signals that mediate survival of endothelial cells is being investigated.
In addition to direct interventions specifically targeting immune checkpoints, signalling pathways that mediate survival of neoplastic B cells, and are the targets of novel therapeutic agents in lymphoma, overlap with pathways controlling T-cell responses.
GSTp is produced downstream of the NRF2 pathway and inhibits JNK1 to stimulate cell survival [ 398– 402] or else transiently inactivates p38MAPK to mediate survival of oxidatively stressed murine 3T3 fibroblasts [ 402].
Similarly, AKT has been described to mediate survival of precursor B-acute lymphoblastic leukaemia (pre-B-ALL) cells through activation of RAFTK, which plays an antiapoptotic role (Sarkar et al, 2002).
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Biofilm formation mediates survival of bacteria in internalized condition (Kroupitski et al. 2009) and motility mediates translocation in plant tissues (Warriner et al. 2003).
In this study we examined how SCF mediates survival of the tubular epithelium during I/R injury.
As these proteins induce apoptosis in the mitochondria and the nucleus, it would suggest that Akt mediates survival of newborn cells in a cell autonomous manner [36], [59], around the time of neuron birth and/or during the two weeks following exercise.
It is part of an integrin signaling complex that mediates survival of cells attached to the extracellular matrix (ECM).
The Flk-1 antagonist SU5416 completely obliterated the protective effect of DC, suggesting that VEGF and Flk-1 are required for DC-mediated survival of CD44+ cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com