RecOR may mediate bridging either in cis, along the same molecule of SSB-coated ssDNA, or in trans to promote annealing of complementary ssDNA.
Accordingly, it is intriguing to note that, based on the relative abundance of c-NHEJ factors in our DNA-PKcs IPs, it is interesting to speculate whether XLS may be directly bound to DNA-PKcs or via Ku, as only Ku factors are present in large enough quantities to mediate the bridging of XLS to DNA-PKcs.
Extrinsic asthma is an IgE mediated hypersensitivity reaction where the bridging of IgE triggers the release of mast cell mediators.
In the indirect model, the binding of anti-DNA antibodies to renal antigens is mediated by a bridge of nuclear antigens, specifically nucleosomes [ 5].
Alternatively, WIP may facilitate the bridging of WASP to these receptors by mediating the interaction with other adaptor proteins [29] or may regulate the function of regulatory proteins such as kinases, known to affect WASP activity [30, 31].
In H. volcanii, cell-cell fusions and cytoplasmic bridges mediate the process of DNA recombination between parental chromosomes [ 51, 52].
Previous studies noted that the advantages of mediating and bridging different groups were highly contingent on environmental factors [ 74, 76, 77].
Structurally distinct from other cellular connections, the first type of EP bridge may mediate transport of cellular material between cells, while the second type of EP bridge is functionally distinct from all other cellular connections by mediating migration of epithelial cells between EP masses.
The stability of short animal toxins is often mediated by the multiple disulfide bridges of paired cysteines.
The SOCS-box may act as a bridge to mediate degradation of target proteins that interact with SOCS3-SH2 by the proteasome pathway.
