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Norfenfluramine did not mediate proliferation of PAH-PASMCs.
This suggests that oestrogen may mediate proliferation of hPASMCs and may contribute to PAH pathology.
We propose that Brk, like other tyrosine kinases, signals downstream to STAT5b to mediate proliferation of breast cancer cells.
Both Dfen and 17β-oestradiol mediate proliferation of hPASMCs and these effects are synergistic at 0.3 μmol/L and 0.1 nmol/L, respectively, which are within therapeutic (Dfen) and physiological (17β-oestradiol) concentration ranges.
In line with this, physiological concentrations of oestrogen mediate proliferation of human PASMCs and an inhibitor of endogenous oestrogen synthesis can reverse the development of PH in female rodents.
Similar(55)
In turn, IQGAP1 activates b-Raf and mediates proliferation of endothelial cells.
Amphiregulin mediates self-renewal in stem cell-like mammary epithelial cells [80], and has been implicated in epithelial remodeling in asthma, with elevated serum levels immediately following asthma attacks and in mediating proliferation of human bronchial epithelium [81].
Live virus was more stimulatory than inactivated virus in inducing DC-mediated proliferation of virus-specific memory CD4+ T cells, suggesting a lack of strong suppression by live virus.
Furthermore, statistical analysis demonstrated that miR-96 expression not only inversely correlated with FOXO3a (r = −0.7577, P<0.001) but also significantly correlated with the Ki-67 level (r = 0.7151, P<0.001) (Figure 6E), which further strengthened the notion that miR-96 mediates proliferation of breast cancer through suppression of the transcriptional factor FOXO3a.
In cultured OVs, IGF-I mediates proliferation of ganglionar neuroblasts by the activation of the RAF/MAPK pathway.
These structures expressed Hoxa10 (homeobox A10), a transcription factor that mediates proliferation of stromal tissue prior to implantation.
Related(20)
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