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Plasmodium falciparum-mediated pathogenesis has been associated with the parasite's ability to mediate binding of its host cell to the vascular endothelium of several organs, notably the brain leading to complications such as cerebral malaria.
HA is knownto mediate binding of viruses to target cells via terminal sialic acid residues in glycoconjugates.
That structure has now been exploited for elucidation of interface pharmacophores that mediate binding of CST to its target, with consequent secretory inhibition.
Mesangial cells express FcγRs and may mediate binding of IC by recognition of exposed Fc-part [41].
Based on previous reports on SSL proteins [14], [15], [22], glycans were mediate binding of SSL5 to glycoproteins.
Among these factors are type IV pili which mediate binding of the bacteria to the host cells.
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Further, it has been demonstrated that the HSP101 binds to this poly CAA) region and mediates binding of initiation factors eIF3 and eIF4G, thereby promoting translation initiation.
SCARB2 mediates binding of EV71 at the cell surface and internalization of the virus via a clathrin-dependent pathway.
The NTR domain also mediates binding of PCPE-1 to cells, an interaction inhibited by heparin, thus suggesting involvement of cell membrane heparan-sulfate proteoglycans (HSPGs).
In particular we focus on the structures of two molecules; the erythrocyte binding antigen, EBA-175 involved in erythrocyte invasion and the VAR2CSA protein that mediates binding of infected erythrocytes to the placenta.
The C-terminal end of Clr4 harbors a SET domain responsible for the enzyme's catalytic activity, while the N-terminal domain contains a chromodomain region that mediates binding of the enzyme to H3K9 methylation groups (Min et al., 2002; Zhang et al., 2008).
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