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The RhoA-mediated mechanism is able to mediate uptake of both gold particles, ricin-HRP and HRP.
For nutrient acquisition, the OM contains a number of channels that mediate uptake of small molecules by diffusion.
Interestingly, hTIM-1 can mediate uptake of viruses independent of the glycoproteins (Moller-Tank et al., 2013; Jemielity et al., 2013; Takada et al., 1997).
Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine – drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor – mediate uptake of atherogenic lipoproteins by macrophages and SMC.
Taken together, these data corroborate the findings of the adhesion assays and gentamicin protection assays and demonstrate that CEACAM1 can mediate uptake of Opa protein-negative meningococci.
The particularity of Gap1 is that it can mediate uptake of all protein amino acids as well as citrulline, ornithine, γ-aminobutyrate (GABA), β-alanine and even D-isomers such as D-histidine.
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The two major renal transporter proteins identified to date are the high affinity transporter URAT1 (SLC22A12) that mediates uptake of urate from the urine into the renal proximal tubular cell, and GLUT9 (SLC2A9/URATv1) which is a voltage-sensitive uniporter that mediates the export of UA from the proximal tubular cell into the circulation[118, 119].
GTL-2 localizes to the basal membrane of the excretory cell, suggesting that it mediates uptake of Mg2+ from the pseudocoelomic fluid.
In relation to this finding, micro-array data also show >2-fold suppression of Lipg (endothelial lipase) that mediates uptake of HDL particles and promotes ApoAI mediated cholesterol efflux [31].
Having shown that integrin α3β1 mediates uptake of Pam3CSK4 into sub-cellular compartments, we next sought to determine whether this internalization is important for the inflammatory response to the ligand.
However, the DC-mediated uptake of tumor antigens is not sufficient to ignite immune response.
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