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Intriguingly, Gli1-lacZ is expressed within a minor subset of p63+ basal cells in Wnt1 tumors and Ihh has been proposed to regulate proliferation of progenitors from stem cells via regulation of p63 isoform expression and to promote human mammosphere formation, considered to be a surrogate in vitro assay of stem cell proliferation [47], [48].
Because Wnt signaling is involved in the regulation of proliferation and apoptosis, and miR-150 is reported to regulate proliferation of breast cancer cells, we think that the functions of these microRNAs include the regulation of cell proliferation and apoptosis.
We also show that these explants replicate aspects of the Notch/Jagged signaling activity that has been shown to regulate proliferation of epithelial cells in vivo.
To this goal, two modified coaxial electrospinning techniques were developed to encapsulate vascular endothelial growth factor (VEGF) and platelet-derived growth factor-bb (PDGF), respectively, to regulate proliferation of vascular endothelial cells (VECs) and VSMCs.
However, most of these genes regulate proliferation of all the neoblast throughout animal body, and it is presently unknown if there exist neoblast intrinsic regulators specifically required for local proliferation responsible for a missing-tissue injury.
CD20 and HTm4 have been shown to regulate proliferation of activated B cells and hematopoietic cells respectively by interfering with cell cycle progression [15], [22].
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VEGF, a key regulator of normal angiogenesis and involved in regulating proliferation of human fetal airway epithelial cells, [ 18] was also included.
The Wnt growth factor family positively regulates proliferation of the intestinal epithelium in vivo.
To investigate the role of G9a SUMOylation in regulating proliferation of myoblasts, pBABE, pBABE-G9a, or pBABE-G9a4KR were pulsed with bromodeoxyuridine (BrdU) and stained with anti-BrdU antibody.
Vascular cells are known to play a prominent role in regulating proliferation of adult neural precursors.
These results show that RASSF9 is involved in suppressing or regulating proliferation of epidermal keratinocytes.
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