Sentence examples for mutant mice based from inspiring English sources

Similar observations have also been reported in KrasV12G compound mutant mice based on the stronger ApcMin allele (Luo et al., 2009).

4) Discussion: elaborate some hypothesis to explain the difference in response to MEK inhibition of mutant mice based on the required revisions above.

The initial development of the Purkinje cell dendritic tree was similar in wild-type and mutant mice based on the extent of the Purkinje cell dendritic area (Fig.  1A).

However, the SB transposon mutagenesis strategy allows for a second option: prioritizing mutant mice based on the genes that are disrupted and establishing homozygous mutant lines for expression and diabetes monitoring.

It has been proposed that the intrinsic mitochondrial apoptosis pathway mediated by caspase-9 and caspase-3 plays a role in the keratinocyte hyperplasia observed in Shpn m/m mutant mice based on the presence of disrupted mitochondria in cpdm skin and in vitro experiments (Liang and Sundberg, 2011).

Previous studies have reported that the prfA* mutants with mid-level PrfA activity (prfA G155S mutants) were fully virulent when intravenously inoculated into mice based on the bacterial CFU required for a 50% lethal dose (LD50) [32].

In Tbx1 mutant mice, branchiomeric myogenesis fails, based on the absence of myogenic regulatory factor activation and lack of subsequent muscle formation.

For these studies we used a scoring system identical to that used in our previously published CIA studies involving P-selectin and intercellular adhesion molecule-1 mutant mice [ 13, 15], based on the methodology of Wooley and others [ 16- 18].

Empirically, it will be up to an individual laboratory to determine how many offspring they can efficiently screen and how they will prioritize mutant mice for subsequent analysis based on the mutation rate of their transgenic lines and available resources.

Crb1 rd8/rd8 mutant mice harbour a single base pair deletion in the Crb1 gene, which results in a premature stop codon.

In addition, given that our mutant mice have a single base deletion as often observed in patients, they could represent a useful model to set up and test novel gene therapy approaches, such as in vivo gene correction by homologous recombination (38), stem cells, or induced pluripotent stem cells from patients.