Sentence examples for mutant viruses based from inspiring English sources

Although evaluation of every observed site under positive selection by reverse genetics would not be realistic or feasible, generation and evaluation of mutant viruses based on sites located within or adjacent to functional domains could provide clues for the genetic aetiology of SARS adaptation to new hosts and emergence.

Third, it was previously predicted that HSV-2 ICP0− mutant viruses should be IFN-sensitive and avirulent [13], [37] based on the fact that multiple HSV-1 ICP0− mutant viruses exhibit these phenotypes [35], [36], [45].

This is based on generation and genotyping of mutant viruses that escape AIC246 (22).

It is improbable that four independent HSV-2 ICP0− mutant viruses would each acquire the expected phenotypes of IFN-sensitivity and avirulence based on secondary mutations randomly scattered throughout portions of the HSV-2 genome outside of the ICP0 locus.

Based on these observations, we have inferred that HSV-2 ICP0− mutant viruses might be useful as a live-attenuated vaccine to prevent genital herpes [13], [37].

Based on their avirulence and immunogenicity, we propose that HSV-2 ICP0− mutant viruses merit consideration for their potential to prevent the spread of HSV-2 and genital herpes.

Based on these results, we propose that interferon-sensitive HSV-2 ICP0− mutant viruses warrant consideration for their potential to prevent the spread of HSV-2 and genital herpes in the human population.

Based on these results, a dose of 100,000 pfu per eye was used to inoculate mice with HSV-2 ICP0− mutant viruses in subsequent tests.

Scientists isolated mutant viruses with that property more than four decades ago.

Many of these attenuated mutant viruses have entered clinical trials.

Both mutant viruses were expected to possess specific metal ion affinities.