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PRotein Ontology (PRO) describes the relationships of proteins and protein evolutionary families and represents the multiple protein forms of a gene locus [11].
Protein Ontology (PRO) [ 88 ], which describes the protein evolutionary classes to delineate the multiple protein forms of a gene locus.
Additionally, multiple protein forms produced from a given gene are referred as isoforms, and polymorphic sequences as variants.
Analytical problems in proteomics are related to the diversity of protein expression (multiple protein forms) and the dynamic expression range (protein abundance).
Interestingly, multiple protein forms were associated with ten of the 17 bldA-influenced protein spots potentially associated with primary/intermediary metabolic processes (central carbon metabolism, amino acid biosynthesis etc), suggesting that the majority of these effects may be indirect subtle changes in post-translational modifications (see Additional File 5).
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ProEvo organizes proteins according to their evolutionary relatedness, while ProForm describes multiple proteins forms derived from a given gene, which arise through variations in splicing or post-translational modifications.
The aforementioned biochemical study suggested that Gomafu interacts with multiple proteins to form a large RNP complex.
In addition, past studies show that mutations in multiple proteins that form a protein complex may lead to the same disease phenotype.
For instance, multiple proteins may form a stable protein complex to regulate gene expression or interact transiently to transduce biological signals.
A common characteristic feature of the WD40 proteins is that, the WD40 domain mediates diverse protein-protein or protein-DNA interactions, thus interplays with multiple proteins to form dynamic complexes and functions as scaffolding protein [ 4, 6].
Therefore, based on an observation from a number of studies that mutations in multiple proteins that form a protein complex may lead to the same disease [ 7, 8, 26- 29], we defined a known disease phenotype-protein complex association as follows: a protein complex is associated with a disease phenotype if at least one of its protein elements is associated with the disease phenotype.
Related(20)
various protein forms
many protein forms
several protein forms
multiple enzyme forms
multiple dosage forms
multiple protein sets
multiple protein concentrations
multiple protein isoforms
multiple protein pairs
multiple protein domains
multiple protein databases
multiple protein variants
multiple protein aggregates
multiple protein bands
multiple protein fragments
multiple splice forms
multiple protein targets
multiple protein sequences
multiple protein kinases
multiple protein structures
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