Sentence examples for multiple protein kinases from inspiring English sources
Examples include libraries of compounds tested for their inhibition potencies across several CYP450; or for their inhibition of multiple protein kinases; or their binding profiles against multiple GPCRs.
For example, it may ultimately be possible to simultaneously monitor multiple protein kinases by affixing fluorophores with distinct photophysical properties to appropriately designed active site-directed peptides.
Stress-dependent hyperphosphorylation of HSF1 by potentially multiple protein kinases has been proposed to, in part, promote HSF1 dependent transactivation [13], [14], [15].
This cell cycle dependent phosphorylation occurs in the absence of DNA damage and is accomplished by multiple protein kinases including cyclin A/cdk2, cyclin E/cdk2, cyclin D/cdk4, and aurora-A [7].
In addition to the abovementioned GSK-3β, C/EBPβ is also targeted by multiple protein kinases including protein kinase A, calmodulin-dependent protein kinase, Erk-1/2, ribosomal protein S6 kinase, and CDK2 [44].
Additionally, recent studies have shown that caspase 9 is the direct target of multiple protein kinases, and the potential role of caspase 9 phosphorylation in the regulation of apoptosis is not well defined [35], [36].
In yeast, nutrient regulation has been studied in great detail and involves multiple protein kinase-mediated signaling pathways.
In addition to the above, both superoxide and hydrogen peroxide contribute to endothelium-independent constriction through activation of multiple protein kinase pathways.
After receptor dimeri-zation, an activation cascade of multiple protein kinase activity and tyrosine autophosphorylation occurs, phos-phorylating several intracellular substrates including Ras-Raf-mitogen-activated protein kinase, phosphatidylinositol-3-kinase (PI3K -Akt, and other imPI3K -Aktignandng that regulates apotherimportantllular proliferation pathwaysignaling0].
Multiple protein kinase transcripts were affected by PB and/or PTU exposure, including the up-regulation of Prkcz (PB and PTU) and PKCα(Prkca), and down-regulation of protein kinase A [Prkaa; GenBank accession no. X57986 (http://www.ncbi.nlm.nih.gov); PTU only].
The activity of ezrin appears to be modulated by multiple proteins kinases, which act through phosphorylation of Ser66 [26], Tyr81 [27], Tyr145, Tyr353 [28] and Tyr477 [29].
