Sentence examples for multiple protein variants from inspiring English sources
Alternative splicing and RNA editing of human TPH2 transcripts generate multiple protein variants with potentially different properties.
Alternative pre-mRNA splicing (AS) enables eukaryotes to generate distinct mRNAs and therefore multiple protein variants from a single gene.
Therefore, it was possible that the extra sequences in EST-only structures contained putative translational start codons, and consequently produced multiple protein variants.
Although KRAS mutations are restricted to a few codons, those in other genes may be scattered along the coding region, which leads to multiple protein variants and hinders potent information on mutant diversity.
Within eukaryotic cells, a process known as alternative splicing allows a single gene to encode for multiple protein variants by ensuring that some exons are included in the final, modified mRNA, while other exons are excluded.
Recent results have suggested that schistosomes create multiple protein variants by splicing micro-exon gene transcripts, which might be involved in immune evasion mechanisms [ 20]; however, the general feature of alternative splicing in the parasites remains understudied.
In the majority of cases (19/23 genes under balancing selection), less than 50% of the genotypes were impacted by frame-shifts or large effect SNPs, with multiple functional protein variants still present.
Since multiple transcript and protein variants expressed by the same gene are, by definition, structurally distinct and need not to be functionally equivalent, the concept of gene orthology should be extended to the transcript level in order to describe evolutionary relationships between structurally similar transcript variants.
In conclusion, multiple Atp7a transcript and protein variants exist in rodent intestinal epithelial cells and are induced by dietary iron deprivation.
To explore a possible role for Atp7a (and copper) in intestinal iron absorption, the current studies were undertaken to test the hypothesis that multiple Atp7a transcript and protein variants exist in intestinal epithelial cells.
By using as few protein scaffolds as possible, we can reduce the spread of contig mappings over multiple protein orthologs or splice variants.
